INVESTIGATIVE STUDY OF STARCH FROM UNRIPE PLANTAIN (MUSA PARADISIACA) PEELS AS BINDER IN THE FORMULATION OF PARACETAMOL TABLET

ABSTRACT

The aim of this research is to compare starch from unripe plantain peel (Musa Paradisiaca) peels with different type of binders in the formulation of paracetamol tablets. The peels were extracted from unripe plantain peels and chopped into pieces (about 0.5cm x 0.5cm) with a stainless kitchen knife and washed severally with tap water to remove sand and other adhering foreign particles. The resulting paracetamol tablets were evaluated for hardness, friability and disintegration time. The extracted unripe plantain peel was found to contain the following phytochemicals –flavonoids, alkaloids and terpenoids. However, steroids, tannins, saponins anthraquinones were absent. The different batches of formulated granules were free flowing with the angle of repose varied from 27.56 ±3.63 to 27.2 ±1.2. The bulk density was found to be in the range of 0.45 ±0.04 to 0.43 ± 0.02. As the granule size increases, bulk density decreases. The tapped density ranged from 0.517 ± 0.024 to 0.517 ± 0.024 while the compressibility index was between 18.92 ±7.609 to 20.31 ±3.925. For hardness test, they were an increase in values as the concentration increased with the range (CSM 3.96 – 5.5, PPS 2.67 to 4.0 and MCC 3.9 to 4.9) kg respectively. Tensile strength of all the samples possesses greater than 1.7 MPa with the range (CSM 4.2-4.8, PPS 2.8-4.2 and MCC 4.1-5.1)N/mm2. Most of the samples were dissolved upon exposure to fluids ranging between 1.3-8.6 min with most of the samples within the standard range of disintegration time. The results for all samples show below 30% which indicates good binding potential in pharmaceutical formulations. Hence it can be concluded that the above formulation of the paracetamol tablet shows a better drug release, disintegration time and friability on all the samples.

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